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Compatible with liquids, solids and gases
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No sample preparation – source integrity preserved
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Compatible with Sciex Turbo-V mass spectrometers
The TEIS is a standalone technique - it provides a rapid ionisation technique without LC for quick identification of compounds. The key benefit of the approach is the lack of sample preparation needed – meaning that a wide variety of methods can be accommodated.
TEIS simply interfaces with Sciex mass spectrometers in the exact same way as the Turbo-V.
The TEIS source operated using a manual injection, directly into the TEIS source itself. That injection is volatilised into a gas and the molecules ionised using APCI instantly. The source is attached to a sample pump, drawing air into the TEIS in the direction of the mass spectrometer so that the ions can enter the mass spectrometer.
The main difference between the TEIS source and a chromatographic injection, is the time it takes for the ions to be detected in the mass spectrometer. Using TEIS, the injection is detected within about 1-2 seconds (in real-time), via a direct injection without any separation. The TEIS source enables rapid identification of compounds within a solid, liquid or vapour within seconds, via direct interaction with the TEIS.
Chromatography would require separation and sample clean-up, extending the method time to at best, a few minutes.
Compounds amenable to thermal desorption, such as many pesticides, drugs and explosives, can be rapidly analysed in this way without the need for any sample pre-treatment, solvents or glassware. Other applications such as drugs in sweat, oral fluids, dried blood spot testing and more have been demonstrated; it is a very versatile ionisation source that could provide a rapid screening solution for many application areas.
The Thermal Extraction Ion Source significantly speeds up workflow times by 30% or more for processes where GCMS is normally used for analysis. Much of the time saved is in the sample queue for analysis, which may be overnight, but there are other savings: no solvents, no glassware, no labelling of vials, no loading up the auto-sampler, no reconciling the queue with the sample list, no reconciling the results to the correct vial in the correct position, no GC columns, no special gases. An added benefit is that the lab would be in a position to give virtually instantaneous results to their clients or colleagues once the analysis is complete.
Download the TEIS Product Sheet