How NXT-Detect works
NXT-Detect identifies chemicals by directly measuring the mass-to-charge ratios of ionised molecules, providing a robust, confirmatory method of identification rather than a screening-based indication. In its primary mode of operation, trace samples collected from hands, surfaces, paper, or packaging are introduced via a thermal desorption interface, which heats the sample to release chemical residues for direct analysis.
For bulk materials, the system uses a direct analysis probe that allows small amounts of solid material to be examined without complex preparation. In both cases, the released molecules are ionised and analysed by a compact mass spectrometer, with results compared against reference libraries.
Because the same analytical core supports both trace and bulk analysis, NXT-Detect delivers consistent, high-assurance results across a wide range of scenarios. Enclosed sampling, controlled exhaust handling, and low consumable use enable safe, continuous operation, while the underlying mass spectral data provides both operators and technical specialists with clear, defensible results suitable for operational, forensic, and industrial environments.
High assurance made easy
The NXT-Detect application software is designed to make high-assurance, compound-specific mass spectrometric analysis accessible to non-specialist operators.
Guided workflows, clear prompts, and automated checks support consistent sample handling and minimise the potential for user error, while results are presented in a clear, decision-focused format rather than raw spectral data.
Complex processes such as method control, library matching, and quality checks are managed automatically, allowing the system to deliver high specificity and confidence without requiring mass-spectrometry expertise.
For specialist users, the underlying Waters MassLynx analytical software remains accessible, enabling full access to raw data and tools for primary research and in-depth analysis. In addition, SpectralWorks AnalyzerPro® XD is available as an optional add-on licence, providing advanced capabilities for method development, spectral interrogation, and expert-level analysis where required.
Trace and Bulk — One Flexible Platform
NXT-Detect brings trace and bulk analysis together by supporting:
Thermal C-TEIS for ultra-sensitive trace detection
Direct bulk material analysis without extensive sample preparation
The result is a single, flexible instrument that reduces equipment footprint, streamlines training, and supports a wider range of operational scenarios.
Availability That Keeps You Operational
Unlike IMS systems, which can retain contaminants in its membrane and therefore require extended burn-out periods, the NXT-Detect thermal desorber self-purges during normal operation.
Samples are rapidly heated in a controlled airflow that removes residues immediately and directs them to a sealed exhaust collection system. Because residues do not accumulate on critical analytical surfaces, background levels recover quickly, enabling continuous operation without enforced downtime while maintaining consistent sensitivity and high-assurance identification.
Technology Confidence
Mass Spectrometry Without Operational Constraints
Many detection systems are limited by fixed regulatory libraries, prescribed workflows, and narrow operating modes. NXT-Detect is intentionally designed to be flexible and adaptable, supporting broader compound coverage and rapid response to evolving threats, while remaining capable of meeting regulatory requirements where needed. The system can operate as a fully standalone solution or be networked to enable secure remote data storage and centralised oversight of multiple instruments from a single control point.
